I personally enjoyed Nick Chase: A Detective Story (played it last year about this time) and Nick Chase and the Deadly Diamond (played last month) more than the Mystery Case Files series. The games are shorter though, not so many hidden object scenes, and more to do it seemed to me. Also, the games felt closer to third-person adventure games, maybe because I like Nick Chase! Liking the characters is always a big plus as far as I'm concerned.
This is maybe why I disliked Nightfall Mysteries: Curse of the Opera. I just could not like those people and didn't care if they were being murdered one by one, so when a slight glitch happened, rather than take the time to work things out, I had my excuse to quit the game.